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Lisdexamfetamine dimesylate was not clastogenic in the mouse charitable marrow micronucleus essai in vivo and was negative when tested in the E. coli and S. typhimurium components of the Ames épreuve and in the L5178Y/TK+- mouse lymphoma assay in vitro. Amphetamine (d- to l-enantiomer facteur of 3:1) did not adversely affect fertility or early embryonic development in the lérot at retenue of up to 20 mg/kg/day.
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